(074) Association of Androgen Receptor Signaling in Human Corpus Cavernosum with Serum Testosterone Levels

Abstract Introduction Testosterone (T) plays an important role in properly developing and maintaining male reproductive tissues. The normal serum testosterone levels can vary between 300 to 1000 ng/dL or 10.4 34.7 nmol/L. However, it is unclear whether androgen receptor signaling based on T the half-life of therapy. What remains unknown there a uniform level above which within tissue similar (saturation hypothesis). Objective We first evaluated varying alter (AR) human penile tissue. Then, we compared AR corpus cavernosum men treated with short-acting vs. long-acting testosterone. hypothesized that would find both eugonadal hypogonadal as well those receiving short Methods obtained (hCC) biopsies during surgery (for erectile dysfunction) from 14 men. recorded their week prior before 10AM. used western blot evaluate adrenergic VEGF protein levels. Men without dysfunction undergoing for Peyronie's disease were controls. Results median age participants was 61 (IQR 12) 325ng/dL 201.45). results showed expression hCC samples >200ng/dL. lower than 200 had decreased AR. Conclusions This finding significant because demonstrates beyond certain threshold may have minimal impact function. If identified, this could be valuable target future studies effects ED. It treatment who ED primary symptom hypogonadism. data also suggests saturation value receptors. Disclosure Any authors act consultant, employee shareholder industry for: Acerus Pharmaceuticals, Boston Scientific, Coloplast, Endo Empower Pharmacy, Nestle Health, Olympus, Hims, Inc